Accutane side effect

The search of appropriate means against acne can be a fairly complex problem, especially for those with large or serious problems with acne. If the condition worsens, it seems, the chances of scar appearance are sharply increasing, that’s why it is so urgently needed to find a cure. Unfortunately, it is very difficult to find the remedy that could really help. In fact, although some medicines against acne help some people, they can not help others. What helps one person, most likely, will not help another one.
If none of the treatments appointed by the doctor did not give positive results, than the course of Accutane is prescribed.
Isotretinoin is a potent mean used for the treatment of acne. Typically, the use of Accutane over 4-5 months leads to the liberation of skin from acne. This is a very effective medicine for almost all types of skin violations.

Isotretinoin belongs to the class of drugs called “retinoid”. Accutane is needed in the event of a very strong expressions of acne with scars and scars that are not operated by other means. It is also used to treat acne, which is present for many years and little exposed to antibiotics in the form of pills and ointments. Although Accutane has many serious side effects, in some ways, its use is safer than prolonged use of antibiotics. Many other drugs used against acne, constitute an antibacterial means which are effective only when the daily application.

Isotretinoin is used for the treatment of other skin violations, including keratosis follicularis, pityriasis rubra pilaris, “fish skin” lamellar ichthyosis, keratosis of palms and soles (keratosis palmaris et plantaris), rosacea and leukoplakia.

Accutane is a natural derivative of vitamin A and can be found in the circulatory system of all people. In large doses vitamin A has the same effect as Accutane - as bad as good. However, it quickly becomes harmful, because of the accumulation in the bones (Important note: do not take vitamin A along with Accutane!).
Large doses of vitamin A, taken during pregnancy, cause the same birth defects as Accutane. Fortunately, this is a substance of natural origin, the body is able to quickly withdraw Accutane from blood channel. It is derived from the body during 9 days. Accutane treats approximately half of people who take it, therefore, these people will never need any other means against acne.

Care of the problem skin is reduced to clarification from contamination and the accumulated skin fat in enlarged pores, which are easily corked and inflame, forming acne on a forehead, nose and cheeks. Care of a problematic skin has its own features - the grease deposit makes it dense and rough and insensitive to usual washing with water. Besides hot water promotes strengthening of activity of sebaceous glands, expansion of excretory channels and it leads to even larger fat-depositing and to gradual increase of porosity.
In care of problematic skin neutral toilet soap or the gel, intended specially for care of problematic skin, are applied. They are applied by massing movements with a soft brush for face.
In care of a problematic skin increase of an acid barrier of a skin (fat skin has alkaline reaction), that interferes with distribution of microbes, is effective. Put sour-milk products - kefir, whey on the face before washing for 5-10 minutes, will help. For the same reasons it is recommended to acidify water by table vinegar for washing (1 tea spoon per 1 l of water), a pinch of lemon acid.
After washing it is necessary to wipe the face with ice and to dry with a soft towel.
Care of a problematic skin after each washing, demands to use clearing, drying, disinfecting, pulling pores together lotions and tonics with the maintenance of zinc oxide and salicylic acid. Or the home-made toilet water containing boric acid, hydrogen peroxide, alum and infusions of grasses of knitting and drying action from medical plants - St. John’s wort, a field horsetail, a cornflower, a sage, coltsfoot, calendula, and mountain ash. These infusions and broths are mixed with a spoon of cologne or vodka and also used for wiping. Sometimes from use of soap and alcohol-containing preparations the problematic skin can be irritated, reddens and is shelled. In this case it is necessary to soften it - is better to do by easy anti-inflammatory hydro gels instead of fat creams. In them a lot of moisture which calms a skin is contained. Emulsion is applied in the mornings on the cleared skin and, patting tips of fingers, rub.
At occurrence of comedons on the face care of a problematic skin demands carrying out of cleaning of skin in the conditions of a cosmetician’s cabinet. But also deep clarification of skin in home conditions is one of the obligatory conditions of care of a problematic skin. It is reached by such means as exfoliants and special masks - they peel and dissolve died off cells of a surface layer of epidermis, which is exclusively favorable environment for reproduction of bacteria, and give smoothness and a healthy look to skin.
Peelings are divided on chemical and mechanical (scrubs). Scrubs are cleared by means of very small firm additives which are put under died off scales on a surface of a skin and break off them. Chemical peelings dissolve died off cells due to presence in them of acids - fruit or an alpha-hydro acids: lactic, apple, lemon. Some peelings contain the enzymes extracted from fruit, for example papaya or kiwi. Frequency of carrying out of peeling in care of a problematic skin should not exceed one-two times a week - more frequent influence can lead to stimulation of work of sebaceous glands.
For deep clarification the special masks deleting from a skin superficial contamination and releasing pores are also applied. The basic component of masks of deep clarification is any kind of clay - being strong absorbent; it absorbs fatty connections from a skin surface. Other elements of masks are acids or enzymes, antiseptic additives, and the components regulating process of fat-discharging and level of humidifying of skin.
Before a peeling or mask the skin at first is washed by usual means, the face is wiped with tonic, and the preparation is densely applied to skin with circular massage movements from the centre of the face to periphery up. The peeling remains on the face about three minutes - for absorption of useful elements and humidifying, the mask should operate not less than 15-20 minutes. After this time the face must be washed by warm water and wiped by tonic.
Care of problematic skin may be done by steam bath 2-4 times a month, better in the evening before a dream. Under the influence of steam skin pores are cleared of black points, skin vessels start to operate more intensively. The warmed skin is better given under influence of other clearing means pulling together enlarged pores and removing the inflammation better. But the main condition of care of a problem skin is a regularity of application of all procedures set forth above which will allow to supervise unpleasant consequences of fat skin and always to feel confident concerning your appearance.

“Accutane” usually makes wonders at the worst form of acne - cystic. The four-monthly course slowly destroys disgusting cysts and nodules, and improvement frequently proceeds also after termination of treatment. For approximately 30 % of the patients a repeated course is necessary. ” Accutane ” is also applied for treatment of persistent extensive papulo-pustular acne.
It is not necessary to use “Accutane” at easy forms of disease such as, drying up and compressing sebaceous glands, it dries up all surface of a body. Almost at each patient accepting it the lips decrepitate, the skin starts to be shelled and scratched, eyes are watering, nasal bleedings and abaissement of hair are sometimes observed. By-effects disappear upon termination of treatment, and the majority of patients agree on such discomfort as the end result surpasses all their expectations.

If any of courses of treatment prescribed by the doctor has not given positive results at nudules and cystic acne then the course of Accutane is prescribed.
This is a strong agent, used for treatment of acne. Usually application of Accutane within 4-5 months leads to remission of an integument of acne. It is a very effective remedy for almost all types of infringements of integument.

Isotretinoin belongs to the class of the medicines named “retinoids”. Accutane is necessary in case of occurrence of very strong implications of acne with cicatrixes and scars, on which other agents do not influence. It is also used for treatment of acne, which are present for many years and are weakly subject to influence of antibiotics in the form of tablets and ointments. Though Accutane has many serious by-effects, in certain respects its use is more safe, than long application of antibiotics. Many other preparations used against acne are anti-infectives, which are effective only at daily application.

Isotretinoin was also used for treatment of other infringements of skin, including keratosis follicularis, pityriasis rubra pilaris, lamellar ichthyosis, keratosis palmaris et plantaris, rosacea and leukoplakia.

Accutane represents natural derivative of vitamin A and can be found out in vascular system of all people. In big doses vitamin A possesses the same effect, as Accutane – both bad, and good. However, it quickly becomes harmful, owing to accumulation in bones (important note: do not accept vitamin A together with Accutane!).

Accutane is formed in an organism, by natural way, from vitamin A, which is present at vascular system. Therefore, big doses of vitamin A accepted at pregnancy, cause the same congenital defects, as Accutane. Fortunately, it is the substance of a natural origin, the organism is capable to deduce quickly Accutane from a blood channel. It is deduced from an organism within 9 days. Accutane “cures” approximately half of people which accept it, therefore, these people never need any other agents against acne.

By-effects

The majority of by-effects of Accutane depend on the dose. As a rule, at appointment of the recommended doses the advantage and risk parity, considering gravity of disease, is comprehensible to the patient.

The symptoms connected with hypervitaminosis A: more often - xeroderma, mucosas of labiums, nasal cavity (bleeding), laryngopharynx (hoarseness of voice), eyes (conjunctivitis, reversible turbidity of cornea and intolerance of contact lenses).

Skin and its appendages: rash, itch, dermatitis of face, sweating, piogenic granuloma, paronychias, onychodystrophy, the strengthened growth of granulation tissue, a proof thinning of hair, reversible abaissement of hair, fulminant forms of acne, hirsutism, hyperpegmentation, photosensitization.

Osteomuscular system: pains in muscles, pains in joints, a hyperostosis and other changes of bones, tendinites. At one patient development of hyperostoses of a backbone and a calcification vertebral ligaments with the subsequent compression of a spinal cord at long (throughout several years) treatment by other preparation of retionoids group is described. Accutane is not intended for long application; however it is necessary to remember about the probability of this by-effect at wrong (too long) application of a preparation.

The central nervous system and mental sphere: behaviour infringements, depression, a headache, rising of intracranial pressure, convulsive attacks.

Sense organs: separate cases of infringements of visual acuity, reduction of acuity of hearing in a certain range of sound waves, photophobia, infringements of adaptation to darkness (reduction of acuteness of twilight sight), cataract, keratitis.

Gastroenteric tract: a nausea, inflammatory diseases of an intestine (colitis, ileitis), bleedings; transitional and reversible rising of activity of transaminases, separate cases of a hepatitis. In many these cases the changes of the norm did not overstep the bounds of norm and came back to initial indicators in the course of treatment, however in some situations there was a necessity to reduce a dose or to cancel Roaccutane.

Breath organs: bronchospasm.

Blood system: reduction of number of leucocytes and erythrocytes, augmentation or reduction of number of thrombocytes, ESR acceleration.

Laboratory changes: hypertriglyceridemia, hypercholesterinemia, hyperuricemia; separate cases of depression of level high-density lipoprotein, especially at appointment of preparation in big dose to predisposed patient (with the family anamnesis burdened by infringement of a fatty exchange, diabetes, adiposity or alcoholism). These changes are also dose-dependent and are normalised after reduction of a dose or cancellation of preparation.

Immune system: local or system infections caused by Gram-positive originators (Staphylococcus aureus).

Other: lymphadenopathy, hematuria, proteinuria, pancreatitis (the risk at patients with hypertriglyceridemia > 800 mg is especially high), vasculitis (Wegener’s granulomatosis).

Safety measures

Accutane should be prescribed only by the doctors, preferably dermatologists, having experience of application of system retinoids and aware about risk teratology at application of Accutane during pregnancy.

It is recommended to supervise function of a liver before treatment, 1 month after its beginning, and then each 3 months. It is necessary to define also level of lipids in serum on an empty stomach (before treatment, 1 month after the beginning and in the end 3-4-months course of treatment).

In rare instances at the patients receiving Accutane, depression, psychotic semiology and suicidal attempts are described. Though their causal relationship with application of preparation is not established, it is necessary to observe extra care at patients with depression in the anamnesis and to observe all patients about occurrence of depression during treatment by a preparation, if necessary referring them to corresponding expert.

Because of possibility of osteal changes it is necessary to prescribe Accutane only at serious forms of disease, carefully estimating a parity of possible advantage and risk and limiting application of preparation only by serious cases of disease.

As acne is an androgen-dependent disease, it is not necessary to apply the contraceptives containing progestinum with androgenic action, for example, derivatives of 19-nortestosteron, especially, if the patient has a gynecologic endocrine pathology.

It is necessary to avoid carrying out of dermabrasion to the patients receiving Accutane, and also within 5-6 months after the termination of treatment because of possibility of the strengthened cicatrisation in atypical places.

During treatment with Accutane and within 5-6 months after it it is impossible to do epilation by means of applications of wax because of risk of development of dermatitis.

The patients from the group of high risk (with diabetes, adiposity, alcoholism or infringements of fatty exchange) at treatment by Accutane may need more frequent laboratory control of corresponding indicators.

At presence of diabetes or suspicion on it more frequent definition of a glycemia is recommended. There are reports on rising of level of glucose in blood on an empty stomach and on cases of disease by diabetes during treatment with Accutane though their causal relationship with reception of preparation is not established.

At patients, who receive or shortly before it (1-2 weeks) received Accutane, it is impossible to take donor blood for transfusion to women of genital age.